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How to resolve Microsoft Exchange Information Store not starting – Event ID 5003

Microsoft Exchange 2010

I was called on to troubleshoot an issue with Microsoft Exchange Information Store not starting recently. All other Exchange services were up and running, but the Information Store wouldn’t start and produced the following error:

“Windows could not start the Microsoft Exchange Information Store on the Local Computer. For more information, review the System Event Log. If this is a non-Microsoft service, contact the service vendor, and refer to the service specific error code – 2147221213.”

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